This symposium explores the issue of integrating spirituality into psychedelic research and therapy, a debate that has garnered significant attention in contemporary scientific circles. At the core of this discourse lies the question of whether spiritual elements should be incorporated into the scientific study and therapeutic application of psychedelics. A faction of researchers and practitioners advocates for a naturalistic or secular approach, suggesting the removal of spiritual notions to maintain scientific rigour. Contrarily, another perspective emphasises the intrinsic nature of psychedelic experiences, which often encompass mystical or spiritual dimensions. Proponents of this view argue for the inclusion of spirituality, citing evidence that mystical-type experiences under psychedelics can lead to positive well-being changes, particularly among healthy individuals. Bringing together both proponents and opponents, this symposium will explore these issues in depth, focusing on the role of spiritual expertise in psychedelic research, the nature and impact of mystical experiences, and the intricate relationship between psychological well-being and spirituality. The goal is to provide a comprehensive and nuanced understanding of this complex subject, appealing to both scientific researchers and therapists involved in psychedelic studies. Through this exploration, the symposium seeks to bridge the gap between spiritual experiences and scientific inquiry, shedding light on how these two realms can coexist and facilitate diversity in psychedelic research.