Psychedelic substances have received renewed scientific investigation, showing strong therapeutic effect and lasting psychological changes. The relationship between psychedelics and aesthetic experience has received little attention, despite frequent anecdotal reports of lasting aesthetic appreciation following psychedelic use. In addition, aesthetic shifts in perception are reported as a significant motivation for recreational use of psychedelics. The present research was designed to bridge the gap at the intersection of psychedelic and aesthetic research. Participants (n = 96) completed aesthetic emotional rating tasks in response to artworks from three categories: abstract, nature and symbolic. They also completed validated measures of aesthetic experience and openness to experience, which were used as covariates. Group differences were explored between those with a history of psychedelic use and a control group of psychedelically-naive participants. Hierarchical multiple regression analyses explored the remaining effects of psychedelic experience when openness and aesthetic experience scores were accounted for. Our findings support the hypothesised relationship between psychedelic use and enhanced aesthetic experiences, across a number of aesthetic emotional domains and independent of covariates. Participants with psychedelic experience were significantly more likely to report feelings of beauty, curiosity and happiness in response to abstract art, less likely to experience boredom in response to all art categories measured, and less calm in response to symbolism art. We tentatively provide the first empirical support for the hypothesis that people who use psychedelics have enhanced experiences of art and offer foundations and suggestions for future research.