Background: N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic known for its intense, transient changes in consciousness, characterised by complex visual imagery, auditory and somatosensory hallucinations, and affective and cognitive alterations. Its unique effects and minimal toxicity make DMT a valuable tool for studying human consciousness and investigating its potential therapeutic benefits for mental health disorders. 

Research question: Here, we explored continuous intravenous (IV) infusion of DMT as a novel method of administration, with the aim of extending the peak effects of the otherwise transient experience into a steady state. Additionally, we investigated the psychological, physiological and EEG effects induced by continuous IV infusions of DMT. 

Methods: In two single-blind, placebo-controlled studies, 28 healthy volunteers received continuous IV DMT in five different doses over 30 minutes. 256-channel EEG activity, DMT plasma concentrations, and autonomic responses were recorded following administration of DMT. Subjective effects were measured acutely via experience sampling and retrospectively via VAS scales, questionnaires, and micro-phenomenological interviews.

Main findings: Continuous IV infusions of DMT were well-tolerated and effective in extending the peak effects of DMT over the duration of the infusion. Marked changes in physiology and subjective experience were observed. The presentation of findings will centre around changes in EEG brain activity induced by continuous IV DMT. 

Conclusion: Continuous IV DMT offers a novel method for prolonged immersion in the DMT state, facilitating research into its phenomenology and effects on human consciousness and its potential therapeutic applications in mental health.