Onaya Science has researched the impact of traditional Shipibo-led ayahuasca ceremonies on mental health since 2016, with ongoing neuroscientific, psychological and biological research into Military Veterans with PTSD. This presentation reports promising preliminary results from a 6-month follow-up pilot study and highlights the necessity for culturally sensitive and ethical research to recognize the impact of these traditional psychedelic practices.  

The pilot study consisted of ten Military Veterans with PTSD undergoing five Shipibo-led ayahuasca ceremonies across ten days. Psychometrics, EEG, and pending epigenetic analysis were collected, with assessments at pre-treatment, post-treatment, and 6-month follow-ups.   

As hypothesised, there were positive impacts on mental health outcomes post-treatment, as indicated by significant reductions in PTSD symptoms, depression, anxiety, impulsivity, and alcohol cravings. Regarding EEG results, alterations in neural activity post-retreat indicated positive changes, reflecting increased brain flexibility and adaptability. 6-month follow-up results for psychometrics and EEG are due to be completed in two weeks. While epigenetic analysis is pending, our previous research suggests that attention to candidate genes, like SIGMAR1, warrants attention.   

These findings underscore the importance of further research into these traditional practices. By better understanding the impact of these traditional practices through scientific exploration, we can begin to recognise and appreciate the accumulation of knowledge embedded in psychedelic practices that predate psychiatry considerably. However, it is imperative to approach such research with utmost care, steering clear of exploitation and appropriation of cultures, values, and traditions. Onaya Science is committed to cultural sensitivity and ethical considerations, exemplified through collaboration and reciprocity with indigenous healers. All of which will be highlighted in the presentation.