There is an undeniable connection between psychedelics, mystical experiences, and religious practices. Yet, there remains disagreement among medical researchers about the extent to which it is ethically appropriate or medically beneficial for religious, spiritual, or mystical ideas and practices to be part of regulated psychedelic medicine. What role does spirituality have in psychedelic healing? Is a truly “secular” psychedelic spirituality possible or are researchers doomed to impose their own psychedelic theologies? What is required for informed consent to be adequately given? Examining these questions legally, medically, and culturally, I conclude that it is necessary to regulate the spiritual and religious dimensions of legal psychedelic use. My interdisciplinary research on this topic will be presented at conferences hosted at Harvard Law School and Harvard Divinity School in 2024 with plans for inclusion in edited volumes. In one paper, I examine the law and policy of psychedelic chaplaincy and argue that it is both medically beneficial and legally necessary to regulate spiritual care as part of psychedelic medicine. In the other paper, I cite religious studies scholarship deconstructing the category of secular to support the conclusion that a secular psychedelic spirituality is an impossibility. In both papers, I stress the importance of this topic due to an observed increase of suggestibility among individuals under the influence of psychedelic medicine shaped by the patient’s “set and setting.” This presentation will summarize both papers, citing relevant medical, anthropological, legal, and religious studies research to support the regulation of psychedelic spiritual care.